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A line graph that shows the overall trend in R&D efficiency (inflation-adjusted) for the United States from 1950 to 2010. The x-axis represents the years starting from 1950 and ending in 2010 with the y-axis representing the rate of decline over 10-year periods.<br /><br />There are three lines in the graph each representing a different period of time. The first line is for the first wave of biotechnology-derived therapies which is the first step in the treatment of HIV/AIDS. The second line is from 1950 which shows that the FDA tightens the regulation of post-thalidomide followed by the FDA clears backlog following PDUFA regulations plus small doses of HIV drugs. The third line is in 2010 and shows that drugs per billion US$ spending is steadily increasing over the years. The graph also shows that adjusting for 5-year delay in spending impact is a significant factor in the overall effect of the FDA's efforts to reduce the number of drugs in the US$ over the past 10 years.

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A line graph that shows the overall trend in R&D efficiency (inflation-adjusted) for the United States from 1950 to 2010. The x-axis represents the years starting from 1950 and ending in 2010 with the y-axis representing the rate of decline over 10-year periods.

There are three lines in the graph each representing a different period of time. The first line is for the first wave of biotechnology-derived therapies which is the first step in the treatment of HIV/AIDS. The second line is from 1950 which shows that the FDA tightens the regulation of post-thalidomide followed by the FDA clears backlog following PDUFA regulations plus small doses of HIV drugs. The third line is in 2010 and shows that drugs per billion US$ spending is steadily increasing over the years. The graph also shows that adjusting for 5-year delay in spending impact is a significant factor in the overall effect of the FDA's efforts to reduce the number of drugs in the US$ over the past 10 years.

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"A line graph that shows the overall trend in R&D efficiency (inflation-adjusted) for the United States from 1950 to 2010. The x-axis represents t...