The cover of the April 2012 issue of the U.S. Pharmacist Product Information Guide. It is titled "Multimodal Approach to Pain Management: Focus on OFIRMEV (acetaminophen) Injection". The cover features an illustration of a human head and neck with the brain on the right side of the image. The brain is shown in a light blue color and the neck muscles are shown on the left side.

In the center of the cover there is a small illustration of an acetaminophen injection which is a type of injection used to treat pain. The injection is shown as a blue liquid and it is connected to the brain by a series of wires. The wires are arranged in a way that they form a network around the brain connecting the brain and neck. The background is a dark blue color. The title of the guide is written in white text at the top of the page and there is the US Pharmacist logo in the top left corner.

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